Introduction: Because they often have atypical symptoms, women are generally under-investigated and under-diagnosed in the direction of ischemic heart disease. The purpose of this study is to evaluate certain characteristics of ischemic heart disease in women compared to men. Methods: There were studied 178 patients admitted with the diagnosis of ischemic heart disease (in various forms) in the Cardiology Clinic of the Rehabilitation Hospital Cluj-Napoca, with a mean age of 63.61 ± 8.93 years, of which 49.44% were women. All patients were evaluated clinically, regarding risk factors, electrocardiographically and echocardiographically. All patients had undergone coronary angiography. Results: 85% (151) of the patients had impaired coronary arteries, as follows: 12% trunk, 61% IVA, 47% RC, 37% Cx. There were no significant angiographic changes in 24.44% men, 54.55% women. Impaired coronaries were more common in men than in women: 62.96% (68) vs 37.04% (40), p = 0.00003. All women who had coronary angiography performed had indication for this exploration (clinical, positive exercise testing, echocardiographic, LBBB present), the final diagnosis formulated for the 48 women without angiographic findings was small coronary artery disease. Compared to men, women with coronary artery disease had statistically significantly higher levels of total cholesterol, 206.8 ± 66.93 vs 169.87 ± 47.09 mg/dl, p = 0.0011 and LDL-cholesterol 132.9 ± 50.81 vs 106.4 ± 38.86 mg/dl, p = 0.0026. Conclusions: In conclusion, small coronary artery disease is more frequent in women than in men. Regarding the cardiovascular risk factors that were analyzed, in women with coronary artery disease compared with men, only dyslipidemia represented an important risk factor for ischemic heart disease.