Clinical and therapeutic profile of women diagnosed with microvascular angina

Introduction: In Europe, the prevalence of cardiovascular mortality in women is very high. The main cause is ischemic heart disease, which has different characte-ristics in women.
Objective: The purpose of this paper is to analyze the clinical and therapeutic profile of women with micro-vascular angina, which is one of the most commonly forms of ischemic cardiopathy found in women.
Methods: A total of 150 women diagnosed with ische-mic cardiopathy, mean age 64.38±9.61, were included in the study. For the diagnosis of ischemic cardiopathy, clinical symptoms, electrocardiogram, echocardiogra-phy, cardiac stress testing and electrocardiographic Holter monitoring / 24 hours were taken into account. All patients underwent invasive examination- coro-narography. Depending on the results of the corona-rography, they were divided into two groups: normal coronary angiography –microvascular angina- group 1 (66.6%) and macrovascular coronary heart disease – group 2 (33.3%).
Results: Women in group 2 had a higher age compared to the first group: 67.7±9.68 vs. 61.07±9.55 (p=0.0001). 81% of women with coronary involvement experien-ced typical angina pain compared to 61% for the first group (p=0.01). There were no differences in smo-king, total cholesterol, LDL-C, triglycerides and obe-sity. In contrast, HDL-C had significantly lower values in patients with macrovascular disease: 44.85±10.29 vs. 40.36±10.39 mg/dl (p=0.01). Similarly, hyperten-sion and diabetes mellitus were more common in group 2 patients: 87 vs. 98% (p=0.035) and 22 vs. 54% (p=0.005), respectively. In terms of electrocardiographic changes in resting conditions, they were present in 69% of group 1 patients and 90% of group 2 patients (p=0.008). 89% of women in the first group experienced ST changes in exercise testing, compared with 62.5% for group 2 (p=0.05). Women in group 1 had a higher ejection fraction than those in group 2: 51.49±0.002 vs. 47.64±0.005% (p=0.001). At the same time, echocardi-graphic kinetics disorders were recorded in a smaller proportion in group 1: 26% vs 60% (p=0.0001).There were no differences in β-blocker prescribing, instead, calcium channel blockers were administered in a signi-ficantly higher percentage in grup 2- 98% vs. 79% (p-0.0043). Antiaggregants and statins were indicated in a higher percentage for group 2 patients: 100 vs. 73% (p=0.0001), respectively 80 vs. 96% (p=0.018).
Conclusions: In conclusion, the clinical and therape-utic profile of women diagnosed with ischemic cardio-pathy differs depending on the form of coronary artery disease.

ISSN – online: 2734 – 6382
ISSN-L 1220-658X
ISSN – print: 1220-658X
The Romanian Journal of Cardiology is indexed by:
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CODE: 379
CME Credits: 10 (Romanian College of Physicians)