Correlation between development of LV aneurysm and cardiovascular risk factors in acute anterior myocardial infarction

Introduction: Anterior myocardial infarction (AMI) is incriminated for the occurrence of left ventricular ane-urysm (LVA). Dyskinesia is present in approximately 1/3 patients in the first two weeks after onset, seriously affecting the quality of life.
Objective: To correlate the incidence of LVA with CV risk factors in patients diagnosed with acute AMI. Methods: T he retrospective study was conducted on 20 patients assessed at the Interventional Department in the Institute of Cardiovascular Diseases from Timi-soara, between January and June 2017, who underwent primary PCI on LAD due to acute AMI. Exclusion criteria: atrial fibrillation, severe valvulopathy, history of previous MI or stenting. After PCI, follow-up was made at 3 months through clinical examination, ECG and TTE.
Results: The group consisted of 85% men (n=17) and 15% women (n=3). All the patients were >60y old and underwent primary PCI on LAD for acute AMI. The mean time from first medical contact (FMC) to primary PCI was 9.31±1.52 hours. At 3 months, 30% (n=6) of the patients developed a post-IM ventricular aneurysm. Multiple CV risk factors were present: male sex -85%, smoking – 70%, dyslipidemia – 80%, HBP – 75%, obesity – 35%, T2DM – 25%. Only one of the 5 diabetic patients developed an aneurysm (16.7%). The Spearman correlation between presence of T2DM and incidence of LV aneurysm was statistically insignifi-cant (rs=0.101, p=0.640). The chi-square test revealed no statistically significant correlations between the in-cidence of LVA and HBP, dyslipidemia, obesity, male sex, but was positive for smoking (p=0.019). Per total, 16.7% patients had only one RF, 66.7% had 3 RF and 16.7% had 4 RF. In the 6 patients with aneurysm, one patient (16.7%) had 2 RF, 4 patients had 3 RF (66.7%) and only one (16.7%) had 4 RF. In the remaining group, 3 patients presented 2 RF (21.4%), 4 patients 3 RF (28.6%), 5 patients 4 RF (35.7%) and 2 patients 5 RF (14.3%). The correlation between the number of cardi-ovascular RF and the occurrence of LV aneurysm was statistically insignificant (rs=0.317, p=0.173).
Conclusions: In our study, development of LV ane-urysm after acute AMI seemed to be independent of the presence and number of cardiovascular risk factors.

ISSN – online: 2734 – 6382
ISSN-L 1220-658X
ISSN – print: 1220-658X
The Romanian Journal of Cardiology is indexed by:
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CODE: 379
CME Credits: 10 (Romanian College of Physicians)