Left atrial mural septic metastasis complicated by endogenous endophthalmitis

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Aura Elena Vijiiac1, Alexandra Gabriela Nestoruc1, Silvia Iancovici1, Sebastian Onciul1,2, Maria Dorobantu1,2


1 Emergency Clinical Hospital, Bucharest, Romania
2 “Carol Davila” University of Medicine and Pharmacy , Bucharest, Romania


Abstract: Infective endocarditis remains a diagnostic challenge, as there are no pathognomonic signs and symptoms for the disease. Intracardiac vegetations are usually found on cardiac valves, but mural, non-valvular vegetations may also be seen, although less frequently. We present the case of a patient with isolated left atrial mural endocarditis complicated with endogenous endophthalmitis, who was successfully treated with antibiotherapy. Keywords: endocarditis, mural vegetation, septic embolism, endogenous endophthalmitis

INTRODUCTION
Despite improvements in diagnostic and therapeutic strategies, morbidity and mortality in infective endo-carditis remain high1. An accurate early diagnostic is not possible when a high index of suspicion is lacking, as most patients with infective endocarditis have only few of the classical clinical hallmarks of the disease.
Intracardiac masses are rare, but they must be tho-roughly evaluated once they are identified, to avoid the risk of systemic embolization and its consequen-ces, including death. Vegetations in infective endocar-ditis tend to colonize intracardiac devices, the low pressure side of the valve structure or the shunt le-sions, while mural endocarditis is generally associated with valvular endocarditis; however, isolated mural vegetations may be encountered2,3, making the diffe-rential diagnosis more challenging. Whether isolated mural vegetations are unusual or just underestimated findings still remains to be determined.

CASE REPORT
A 55 year-old obese female with poorly controlled diabetes presented to our unit with a 2 week-histo-ry of unexplained fever (up to 39°C). She had poorly controlled diabetes as a consequence of her constant refusal of insulin therapy and otherwise she had no risk factors for immunosupression. She had been complaining of fever for 2 weeks, for which she was prescribed antipyretics and adequate hydration. She was apyretic on admission and the clinical examination was unremarkable, except for tachycardia at 110 bpm. The lab workout showed an elevated white blood cell count (29000/mm3) and a high ESR (50 mm/h), with severe hyperglycemia. Urine culture came back nega-tive and her chest X-ray was normal. Her abdominal ultrasound revealed 3 liver masses and we raised the suspicion that these were septic emboli.
A transthoracic echocardiogram (TTE) was perfor-med, which showed a hypermobile, isolated left atrial mass (Figure 1), with normal morphology and function of all cardiac valves. The left ventricular function, the interatrial- and interventricular septum were normal and there was no pericardial effusion. The transoeso-phageal echocardiography (TOE) confirmed the pre-sence of a 17/14 mm sessile, mobile, polylobulated left atrial mass attached to the anterior wall of the left atrium, in the vicinity of the aortic sinotubular juncti-on (Figure 2-5). No other cardiac abnormalities were noted. The full-body CT scan confirmed the liver masses, highly suggestive of abscesses; there were no other septic emboli in the brain or in other abdominal or-gans. 24 hours after the admission, the patient’s ri-ght eye became red and painful (Figure 6), and the ophthalmologic evaluation confirmed the diagnosis of endogenous endophthalmitis. Repeated blood cultu-res came back positive for Klebsiella spp.
Taking the whole picture into account, with fever, ocular and hepatic emboli, intracardiac mass and per-sistently positive blood cultures, our patient fulfilled the Duke criteria for infective endocarditis. At that point, as there was no clear indication for surgery1, a multidisciplinary decision was taken together with the infectious disease specialist in favor of systemic antibi-otherapy. Intravenous amoxicillin (2 g every 4 hours) plus a synergistic dose of gentamicin were given for 6 weeks, according to the antibiogram. The clinical course was favorable; the patient remained apyretic, the white blood cell count came back to normal and the ocular signs gradually diminished during the first month. After completing her course of antibiotics, the patient underwent a follow-up echocardiogram, which revealed the complete disappearance of the left atrial mass. The follow-up abdominal CT scan showed the disappearance of the liver abscesses as well. There was no clinical suggestion of recurrent embolization during six-month follow-up.

Figure 1. TTE, apical 4-chamber view. Visualization of a left atrial mass (red arrow).

Figure 2. TOE, mid-esophageal aortic valve short-axis view. Left atrial vegetation (red arrow).

Figure 3. TOE, mid-esophageal aortic valve long-axis view Left atrial poly-lobulated vegetation (red arrow).

Figure 4. TOE. 3D visualization of the left atrial vegetation. VEG=vegetation, MV=closed mitral valve.

DISCUSSION
Predisposing factors for endocarditis in patients wi-thout previous heart disease are: diabetes, renal failu-re, malignancy, severe chronic obstructive pulmonary disease, immunosuppressive therapy and intravenous drug use4. Klebsiella is not a typical etiologic agent of infective endocarditis, the non-HACEK Gram-nega-tive bacilli endocarditis being usually encountered in immunosupressed patients. Our patient had poorly controlled diabetes as a sole predisposing factor for infective endocarditis. No obvious source of Klebsiella bacteremia could be found in our patient. She had no recent hospitalization requiring long-term intravenous catheters, no recent previous history of either res-piratory or urinary tract infection and two repeated urine cultures came back negative.
The differential diagnosis of intracardiac masses must include thrombi and tumors. Our patient had no predisposing conditions for atrial thrombosis, the left atrial dimensions were normal and there was no spontaneous echo contrast either in the atrium or in the left atrial appendage. Atrial myxomas are the most frequent primary tumors; they are generally attached to the interatrial septum at the site of the fossa ova-lis5. Even though myxomas may be – rarely – attached to the anterior atrial wall, our patient’s outcome with complete disappearance of the atrial mass under an-tibiotherapy confirmed that it was a septic mass and not a tumor.
Mural infective endocarditis usually occurs in asso-ciation with valvular vegetations, either as a con-sequence of jet lesions or by direct spreading of the infection from adjacent tissues6,7. Mural seeding usu-ally involves previously abnormal endocardium affec-ted by mural thrombi, fibrosis, jet lesions, congenital defects, primary cardiomyopathies, pacemaker leads or radiofrequency ablation8. It is difficult to establish the sequence of events leading to such a rare pre-sentation in our patient. A possible theory is direct inoculation of bacteria at the site of an endocardial lesion; however, she had no obvious predisposing fac-tors for atrial endocardial injury. Since the atrial mass occurred in the absence of co-existing valvular vege-tations, we assumed that it was actually a mural septic metastasis with the same etiopathogenic mechanism as the ocular and hepatic emboli.
Endogenous endophthalmitis is a rare complication of infective endocarditis, which occurs when bacteria reach the eye by hematogenous spreading from a re-mote source, causing inflammation of the intraocular tissues9. Most cases of endophthalmitis are exogeno-us, following ocular surgery of trauma. Endogenous endophthalmitis accounts for a small proportion of all cases of endophthalmitis, the most frequent un-derlying medical condition being infective endocardi-tis, followed by urosepsis, abdominal abscesses, me-ningitis and septic arthritis10. The condition is most often unilateral, and the right eye is more frequently involved than the left, possibly because the right ca-rotid artery provides a relatively direct route to the eye11. It requires systemic antibiotic treatment, as the-re is no clear evidence regarding the benefit of intra-vitreal antibiotics12.
The true incidence of isolated mural endocarditis is not known and its complications are unpredictable. The current guidelines 1 provide clear recommenda-tions for the surgical management of valvular, but not mural infective endocarditis. It is generally accepted that surgery must be performed in clinical scenarios such as obstructive or growing vegetations, myocar-dial abscesses, heart failure or recurrent embolism despite antibiotic therapy. Previous cases of uncompli-cated mural endocarditis treated with antibiotherapy alone have been reported13,14, and our patient had a fa-vorable clinical outcome with medical treatment only.
Patients with fever of unknown origin should un-dergo TTE in order to carefully exclude infective en-docarditis as an etiology for the patient’s symptoms. If TTE is inconclusive, the improved spatial resolution of TOE enables an optimal evaluation of such patients15. When screening for septic sources, 3D TEE allows de-tailed visualization of all cardiac structures in different views and planes, thus minimizing the risk of delayed diagnostic or misdiagnosis.

Figure 5. TOE. 3D visualization of the left atrial vegetation in multiple views.

Figure 6. Endophthalmitis of the right eye.

CONCLUSION
Fever and septic emboli in major organs are classical hallmarks of infective endocarditis; the latter are so-metimes the first manifestation of the disease, thus making a comprehensive echocardiographic evaluation irreplaceable for an accurate diagnostic. Mural septic metastases, although unusual, should be considered and carefully excluded among all cases of suspected infective endocarditis, even when all cardiac valves ap-pear to be perfectly normal. This also requires a high index of suspicion since isolated mural vegetations are usually silent on cardiac examination. Even though the management of endocarditis often requires cardiac surgery, some cases can be successfully treated with antibiotherapy alone.

Conflict of interest: none declared.
References:
1. Habib G, Lancellotti P, Antunes MJ, Bongiorni MG, Casalta JP, Del Zotti F, Dulgheru R, El Khoury G, Erba PA, Iung B, Miro JM, Mulder BJ, Gosciniak EP, Price S, Hesselink JR, Martin US, Thuny F, Mas PT, Vilacosta I, Zamorano JL. 2015 ESC Guidelines for the Management of Infective Endocarditis. The Task Force for the Maagement of In-fective Endocarditis of the European Society of Cardiology (ESC), Endorsed by: European Association for Cardio-Thoracic Surgery (EACTS), the European Association of Nuclear Medicine (EANM). Eur Heart J 2015;36:3075-3123.
2. Siddiqui WJ, Acharya I, Iyer P, Khan MY, Rafique M, Kaji A, Gala K. Vegetation Attached to the Left Interatrial Septal Surface at the Congenital Location of the Foramen Ovale: A Rare Occurrence. Am J Case Rep 2016;17:837-840.
3. Ahmed I, Katz DH, Crooke GA, Li M, Doddamani S, Haramati LB, Ostfeld RJ, Gordon GM, Spevack DM. Biventricular Mural Vegeta-tions in A Patient without Valvular Pathology. J Am Soc Echocar-diogr 2006;19(7):938.e5-7.
4. Castillo JC, Anguita MP, Torres F, Siles JR, Mesa D, Valles F. Risk Factors Associated with Endocarditis without Underlying Heart Dis-ease. Rev Esp Cardiol 2002;55(3):304-307.
5. De Isla LP, De Castro R, Zamorano JL, Almeria C, Moreno R, More-no M, Lima P, Garcia Fernandez MA. Diagnosis and Treatment of Cardiac Myxomas by Transesophageal Echocardiography. Am J Car-diol 2002;90:1419-1421.
6. Gregory SA, Yepes CB, Byme JG, D’Ambra MN, Chen MH. Atrial Endocarditis – the Importance of the Regurgitant Jet Lesion. Echo-cardiography 2005;22:426-430.
7. Yong CJ, Sik KK. Left Atrial Mural Endocarditis Diagnosed by Trans-esophageal Echocardiography in a Patient with Mitral Valve Prolapse. J Cardiovasc Ultrasound 2008;16(3):84-86.
8. Vijay SK, Tiwari BC, Misra M, Joshi LM. The Vanishing Right Ven-tricular Masses. Heart India 2013;1:17-19.
9. O’Brien S, Dayer M, Benzimra J, Hardman S, Townsend M. Strep-tococcus Pneumoniae Endocarditis on Replacement Aortic Valve with Panophthalmitis and Pseudoabscess. BMJ Case Reports 2011;doi:10.1136/bcr.06.2011.4304.
10. Lee SY, Chee SP. Group B Streptococcus Endogenous Endophthal-mitis: Case Reports and Review of Literature. Ophthalmology 2001;109(10):1879-1886.
11. Forster RK. Endophthalmitis. In Tasman W, Jaeger EA. Duane’s Clin-ical Ophthalmology. Philadelphia: JB Lippincott, v4, chapter 24, 1998.
12. Sadiq MA, Hassan M, Agarwal A, Sarwar S, Toufeeq S, Soliman MK, Hanout M, Sepah YJ, Do DV, Nguyen QD. Endogenous Endophthal-mitis: Diagnosis, Management and Prognosis. Journal of Ophthalmic Inflammation and Infection 2015;5:32
13. Wilson AM, Lu YR. Two Cases of Right Atrial Mural Endocarditis Caused by Staphylococcus aureus. Heart Lung Circ 2016;25;10:119-121.
14. Bayram NA, Ayhan H, Keles T, Durmaz T, Bozkurt E. Medical Treat-ment of Mural left Ventricular Endocarditis Mass: A Case Report. Perfusion 2010;25:175-177.
15. Tahara M, Nagai T, Takase Y, Takiguchi S, Tanaka Y, Kunihara T, Arakawa J, Nakaya K, Hamabe A, Gatate Y, Kujiraoka T, Tabata H, Katsushika S. Primary Mural Endocarditis without Valvular Involve-ment. J Ultrasound Med 2017;doi:10.7863/ultra.16.03049.

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