Decebal Gabriel Latcu1, Bogdan Enache1,2, Nazih Benhenda1, Dragos Cozma2, Ruben Casado-Arroyo3, Frédéric Anselme4, Atul Pathak1, Nadir Saoudi1
1 Centre Hospitalier Princesse Grace, Monaco, France
2 „Victor Babes” University of Medicine and Pharmacy, Timisoara, Romania
3 Department of Cardiology, Erasme Hospital, Université Libre de Bruxelles, Belgium
4 Department of Cardiology, Rouen University Hospital, Rouen, France
Abstract: Introduction – The current scientifi c literature suggests similar or even better catheter contact on caval regions of the cavo-tricuspid isthmus (CTI) compared to the more medial or annular part. Yet CTI ablation can be challenging owing to instability at the inferior vena cava (IVC) edge. No study specifically addressed the issue of catheter-tissue contact on caval/mid/annular regions of the CTI. Methods – Twenty-seven patients (22 men, 67±12 years) underwent typical atrial fl utter ablation with a contact force (CF) sensing catheter (Tacticath 75, Abott) and were prospectively included. Operators aimed at optimizing CF for all RF pulses. The product of CF, time (force-time integral; FTI) and delivered power (FTPI) has been proposed as an estimate of lesion size. In a subset of 8 consecutive pts, electrograms (EGM) of all RF lesions were analyzed. Annular CTI was defined as sites showing both atrial and ventricular near-field bipolar EGM. Mid CTI sites had only atrial near field bipolar EGM on both distal and proximal dipoles (or distal only in case of superior-to-inferior approach). Caval sites had near-field bipolar EGM only in distal dipole, while the proximal one was inferiorly located. Results – Complete persistent (at 30 min) CTI block was obtained in all patients. A steerable sheath was used in 12 pts (44%). Procedure duration was 93±30 min, RF delivery time 10±6 min, fluoroscopy time 14±8 min. Mean CF was 15.8±5.9 g. CF was significantly lower (11.1±9.7 g) at the caval CTI than at mid CTI (19.9±11.8 g) and annular CTI (20±12.2 g; p=0.001). CF and FTI were higher during sinus rhythm than during Fl (23.2±15.3 vs 18.5±15.4 g, p=0.04 and 677±432 vs 532±357 gs, p=0.03). Use of a sheath improved mean CF (24.4±12.5 vs 18.4±14.9 g, p=0.01) but this was not significant at caval sites (17.5±11.4 vs 12.6±10.7 g, p=0.31). Conclusion – Applied forces are significantly lower at the IVC edge during CTI ablation. This supports the use of a steerable sheath in challenging cases. Keywords: atrial flutter, contact force, cavo-tricuspid isthmus.
Experimental data shows that the quality of the electrode-tissue contact (the contact force; CF) is a major determinant of the depth/size of RF lesions1,2. For that reason CF-sensing catheters became the gold stan-dard in complex ablations3,4. Typical atrial flutter (AFL) and its ablation were, be-fore the rise of atrial fibrillation ablation, the subject of extensive research. While in the last decade publications on this subject have been scarce, and abla-tive treatment very effective, the electrophysiology community accommodated with classical knowledge about the isthmus dependent AFL. Even if some of this knowledge is now challenged5, ablation at the level of the cavo-tricuspid isthmus remains the cornerstone of typical AFL ablation6. Literature data suggests similar or even better ca-theter contact on caval regions of the cavo-tricuspid isthmus (CTI)7. Yet CTI ablation can be challenging owing to instability at the inferior vena cava (IVC) edge. No study specifically addressed the issue of ca-theter-tissue contact on caval/mid/annular regions of the CTI.
Patients scheduled for typical atrial flutter ablation with a contact force sensing catheter (Tacticath 75, Endosense) in our center (Centre Hospitalier Prin-cesse Grace, Monaco) were prospectively included. The study was approved by the institutional com-mittee on human research. According to institutional guidelines all patients were informed and gave their written consent for the invasive procedures and the study. Antiarrhythmic drugs were withdrawn at least five half-lives before the procedures (except amio-darone, interrupted one month before). All procedures were performed with an uninterrup-ted anticoagulation regimen: vitamin K antagonists with a 2 to 3 International Normalized Ratio or direct oral anticoagulants with the last administration of the drug 12 (for dabigatran and apixaban) or 12 to 24 (for rivaroxaban) hours before the procedure. Ablation procedures have been performed in a fas-ting state, under local anesthesia and mild intravenous sedation (midazolam 1 to 2 mg). During RF delivery, pain control was obtained by intravenous 1 to 3 mg of nalbuphine. By an echo guided right femoral veno-us approach were inserted: a decapolar halo catheter (Inquiry H, Irvine Biomedical Inc., Irvine, CA; IBI) pla-ced on the tricuspid annulus with its distal tip in the antero-inferior right atrium and a large-curve steera-ble 3.5-mm-irrigated-tip CF ablation catheter (Tactica-th 75). A minority of patients, at the operator’s discre-tion, had coronary sinus (CS) catheterization with a decapolar diagnostic catheter (Inquiry™ L, 2-5-2 mm spacing, Saint Jude Medical-SJM). Operators aimed at optimizing CF (e.g. > 10 g) for all RF pulses. If necessary, a steerable sheath was used for the ablation catheter (Agilis, SJM). Most often, CF varies with cardiac cycle and respiratory movements (Figure 1); this variation is integrated in a more power-ful contact parameter – the force-time integral (FTI). Electrograms were acquired on a digital electrophy-siological recording system (Prucka Engineering, Inc., Houston, TX, USA), with a sampling rate of 1 kHz. Bipolar signals were recorded with a 30 to 500 Hz fil-tering and a 50 Hz notch pass. Morphological analysis and measurements of the bipolar EGM on the distal poles of the ablation catheter were performed simultaneously after the procedure by two electrophysiolo-gists. Amplification and display speed were optimized. Poor quality EGMs, mainly due to artifacts, were ex-cluded from the final analysis. Each CTI line was divided in 3 segments (Figure 2): annular CTI (next to the tricuspid valve), mid CTI (in the middle of the cavo-tricuspid isthmus) and the caval CTI (posteriorly located). Annular CTI was defi ned as sites showing both atrial (A) and ventricular (V) near-field bipolar electrograms (EGM). Mid CTI sites had A near field bipolar EGM on both distal and proximal dipoles (or distal only in case of superior-to-inferior approach). Caval sites had near-field bipolar EGM only in distal dipole, while proximal one was inferiorly lo-cated. RF was delivered with a Stockert 70 generator (BW) with a 42°C target temperature. Power setting was adjusted between 20 and 35 W. The catheter was continuously irrigated at 17 (for power ≤ 30 W) to 30 ml/min (for a power setting of 35 W) with 0.9% NaCl. Duration of each RF application was left to the operator’s appreciation, aiming at an FTI of 700 gs.3 Care was taken to perform ablation in a point-by-point manner for 20 to 30 s. Successful ablation was defined by completion of bidirectional CTI block (clo-ckwise block proven by anterior right atrium activati-on sequence during septal CTI pacing) with a waiting time of 30 minutes.
Figure 1. Contact force (CF) variability with cardiac cycle and with respiratory movements. (A) good contact, (B) variable contact, (C) poor contact, (D) respiratory variations. Dynamic range is depicted (yellow arrows).
Figure 2. EGM and fluoroscopy-based classification of CTI sites (identical gain). Annular CTI was defi ned as sites showing both atrial (A) and ven-tricular (V) near-field bipolar electrograms (EGM). Mid CTI sites had A near field bipolar EGM on both distal and proximal dipoles (or distal only in case of superior-to-inferior approach) and absence of near-field V EGM. Caval sites had A near-field bipolar EGM only in distal dipole (without near-fi eld V), while proximal one was inferiorly located.
Continuous variables are expressed as mean ± SD. Numerical variables were compared with the t-test or the Mann-Whitney-Wilcoxon test (in case of non-normality). Nominal variables were compared using of the chi-squared test or Fisher’s exact, as appropriate. Simultaneous multiple comparisons were performed using ANOVA. P<0.05 was considered significant.
Twenty-seven patients (22 men, 67±12 years) were included. Complete persistent (at 30 min) CTI block was obtained in all patients. A steerable sheath was used in 12 pts (44%), mainly due to the impossibility of reaching the anterior aspect of the CTI without the sheath. Overall procedure duration was 93±30 minu-tes, RF delivery time 10±6 min, fluoroscopy time 14±8 min. Mean CF was 15.8±5.9 g. In a subset of patients (n=8), all RF lesions were analyzed. For the 142 analyzed RF applications, con-tact parameters by site are depicted in the Table 1. Despite contact optimization, CF at beginning of RF (including its lateral and axial components) was sig-nificantly lower at caval CTI than at the mid CTI and annular CTI. Mean CF (for the entire RF pulses) was also lower at caval CTI (Figure 3). CF and FTI were higher during sinus rhythm than during flutter (23.2±15.3 vs 18.5±15.4 g, p=0.04 and 677±432 vs 532±357 gs, p=0.03). Use of a sheath improved mean CF (24.4±12.5 vs 18.4±14.9 g, p=0.01) but this did not reach statistical significance at caval sites (17.5±11.4 vs 12.6±10.7 g, p=0.31).
Figure 3. Mean contact force (g) over the entire duration of each RF pulse for the 3 predefined CTI regions.
We found that despite the operator’s efforts to uni-formly optimize contact in all CTI regions, CF was sig-nificantly lower at the caval CTI than at mid and annu-lar CTI. CF and FTI were higher during sinus rhythm than during flutter. In difficult cases, the use of a ste-erable sheath helped reaching the anterior (annular) CTI but also improved mean CF.
CF sensing technologies
CF catheters have become the gold-standard of radio-frequency ablation nowadays. Three CF sensing cathe-ters with different technologies exist. The Tacticath8, a 7-French 3.5 mm open irrigated tip catheter, has embedded 3 optical fibers which allow measurement of both the magnitude and direction of the CF; this information as well as the force-time integral (FTI) and the lesion-size index (LSI) for each RF application are displayed on a dedicated screen (Tactisys, Endosense) or on the mapping system (Ensite Precision, Abbott). The ThermoCool SmartTouch Catheter (Biosense Webster; BW, Inc., Diamond Bar, California) uses a small spring connecting the ablation tip electrode to the catheter shaft with a magnetic transmitter and sensors to measure microdeflection of the spring9. In-formation like CF, FTI but also the integrative ablation index is directly displayed on the mapping system (Car-to 3, BW). The IntellaNav StablePoint catheter (Boston Scientific) combines the microinductive method of measuring force with a spring and the assessment of the catheter-tissue electrical coupling by means of the measurement of the local (bipolar) impedance and is at the dawn of its clinical use10.
Results in perspective
Obtaining an optimal CF is commonly considered as dependent on operator skills. If respiratory and car-diac cycle variations of CF are obvious and have been documented in the literature7 the anatomical depen-dence of CF is less known. Kumar et al7 reported in a 15 patients group undergoing CTI ablation similar or higher CF at the caval CTI when compared with mid and annular CTI, irrespective of ventilation (ap-nea or not). In their study, the CTI was divided into 3 equidistant segments (annular, mid, and caval) for the purpose of data analysis. This allowed region specific assessment of CF but is very different from the seg-mentation in our study, based on EGM interpretation, and closer to what operators may encounter in clinical practice. Indeed, purely caval CTI is the posterior CTI with a downslope favoring inferior catheter dislodge-ment when a higher pressure in applied. This is why, in our opinion, a stable position of the ablation catheter in this part of the CTI is only obtained with a lower CF. Alternately, the use of a sheath might provide a support preventing catheter dislodgement for incre-ased CF. This phenomenon is also encountered in other atri-al and ventricular particular regions. Tissue distortion created by increased CF leads to catheter dislodge-ment and instability, limiting CF in regions like cari-na (inter venous ridge between ipsilateral pulmonary veins7, but also anterior segment of the left pulmo-nary veins at the level of the ridge between left PV and left atrial appendage or at papillary muscles in the left ventricle. Beyond the use of a steerable sheath, to improve stability, cryotherapy has been proposed to overcome this technical limitation11. Another anatomical factor may play a role limiting the CF at the caval CTI: the existence of a promi-nent Eustachian valve/ridge. Moreover, a distinct sub-eustachian pouch was documented in up to 32% of patients in anatomical studies, most often located at the posterior and middle istmus12. In many cases, the Eustachian valve and ridge form a line of conduction block between the inferior vena cava (IVC) and the coronary sinus (CS) ostium13. The electrophysiological implications with the corresponding variants of typical atrial flutters have been discussed elsewhere14.
Applied forces are significantly lower at the IVC edge during CTI ablation. This supports the use of a steera-ble sheath in challenging cases.
Conflict of interest: none declared.