Physical training and insulin resistance

Introduction: EUROASPIRE studies underlined unfavorable trends in lifestyle, especially in terms of nutrition and physical activity. The increasing number of cases of diabetes in hypertensive increases cardiovascular risk in this category of patients. Insulin resistance is an intermediate stage in the occurrence of diabetes mellitus. Cardiovascular rehabilitation programs and individualized physical training with abdominal obesity ameliorate hemodynamic and metabolic parameters. Methods: We evaluated a total of 22 hypertensive nondiabetic patients with abdominal obesity, enrolled in a cardiovascular rehabilitation program, which followed an individualized physical training program for 6 months. Patients were evaluated initially (clinically, laboratory and the capacity of effort) and at the end. Insulin resistance was evaluated using the Homeostasis Model Assessment for Insulin Resistance (HOMA-IR). Results: After 6 months of physical training: corporeal mass index decreased with 3.18 kg/m2 (p = 0.0000), HOMA-IR decreased with 1.7 (p 0.0000), systolic blood pressure decreased with 8.18 mm Hg (p 0.0114), enddiastolic blood pressure decreased with 3.86 mm Hg (p 0.0234), total serum triglyceride level decreased with 23.28 mg/dl (p 0.0323). Conclusions: Physical training along with other means of primary and secondary prevention improve hemodynamic and metabolic status by decreasing insulin resistance and thus global cardiovascular risk.

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